diff --git a/.config/git/ignore b/.config/git/ignore
index ee17658..cbfb1af 100644
--- a/.config/git/ignore
+++ b/.config/git/ignore
@@ -5,6 +5,14 @@
 *.temp
 *.tmp
 
+# Python
+__pycache__/
+*.py[cod]
+.python-version
+.venv/
+venv/
+.env
+
 # Vim
 # Source: https://github.com/github/gitignore/blob/main/Global/Vim.gitignore
 #
diff --git a/.config/pypoetry/config.toml b/.config/pypoetry/config.toml
new file mode 100644
index 0000000..a815e69
--- /dev/null
+++ b/.config/pypoetry/config.toml
@@ -0,0 +1,9 @@
+[virtualenvs]
+
+create = true
+in-project = true  # .venv/ inside the project, not a central cache
+
+
+[installer]
+
+parallel = true
diff --git a/.config/python/startup.py b/.config/python/startup.py
new file mode 100644
index 0000000..b928bbc
--- /dev/null
+++ b/.config/python/startup.py
@@ -0,0 +1,54 @@
+"""Move Python's history file to "$XDG_STATE_HOME/python/history".
+
+Python 3.13+ honors the `$PYTHON_HISTORY` environment variable,
+so this file is only needed for older interpreters (e.g., via `pyenv`).
+
+`$PYTHONSTARTUP` is executed in the REPL's own namespace
+=> Everything is wrapped in a function that is deleted afterwards
+   to avoid polluting the prompt with temporary names
+"""
+
+import sys
+
+
+def _setup_history():
+    if sys.version_info >= (3, 13):
+        return  # `$PYTHON_HISTORY` handles it
+
+    try:
+        import readline  # because it is not in every build
+    except ImportError:
+        return
+
+    import atexit
+    import os
+
+    state_home = os.environ.get("XDG_STATE_HOME") or os.path.join(
+        os.path.expanduser("~"), ".local", "state"
+    )
+    history_file = os.path.join(state_home, "python", "history")
+
+    os.makedirs(os.path.dirname(history_file), exist_ok=True)
+    if os.path.isdir(history_file):
+        raise OSError(history_file + " must not be a directory")
+
+    try:
+        readline.read_history_file(history_file)
+    except OSError:  # `$PYTHON_HISTORY` is non-existent or unreadable
+        pass
+
+    readline.set_auto_history(True)
+    readline.set_history_length(99999)
+
+    def write_history():
+        try:
+            readline.write_history_file(history_file)
+        except OSError:
+            pass
+
+    atexit.register(write_history)  # Keep a reference to `write_history`
+
+
+_setup_history()
+
+del _setup_history
diff --git a/.config/shell/aliases b/.config/shell/aliases
index 522f114..0f47b0e 100644
--- a/.config/shell/aliases
+++ b/.config/shell/aliases
@@ -112,3 +112,27 @@ if _command_exists git; then
     alias gsua='git summary --all'
 
 fi
+
+
+# Make working with Python more convenient
+
+alias py='python3'
+
+ipy() {
+    if command -v ipython >/dev/null 2>&1; then
+        ipython "$@"
+    else
+        ipython3 "$@"
+    fi
+}
+
+if _command_exists poetry; then
+    alias pr='poetry run'
+fi
+
+if _command_exists pyenv; then
+    alias pyvenvs='pyenv virtualenvs --bare --skip-aliases'
+    alias pyver='pyenv version'
+    alias pyvers='pyenv versions --skip-aliases'
+    alias pywhich='pyenv which'
+fi
diff --git a/.config/shell/env b/.config/shell/env
index cb957f5..76e188f 100644
--- a/.config/shell/env
+++ b/.config/shell/env
@@ -25,6 +25,7 @@ export DOTFILES_DIR="$XDG_DATA_HOME/dotfiles"  # also set in ~/.local/bin/instal
 export EDITOR=vim
 export GPG_TTY=$(tty)
 export PAGER="less --chop-long-lines --ignore-case --LONG-PROMPT --no-init --status-column --quit-if-one-screen"
+export PYTHONDONTWRITEBYTECODE=1
 export TZ="Europe/Berlin"
 export VISUAL=$EDITOR
 
@@ -39,4 +40,7 @@ fi
 export BAT_CONFIG_PATH="$XDG_CONFIG_HOME/bat/config"
 export LESSHISTFILE="$XDG_STATE_HOME/less/history"
 export PSQLRC="$XDG_CONFIG_HOME/psql/psqlrc"
+export PYENV_ROOT="$XDG_DATA_HOME/pyenv"
+export PYTHON_HISTORY="$XDG_STATE_HOME/python/history"
+export PYTHONSTARTUP="$XDG_CONFIG_HOME/python/startup.py"
 export VIMINIT='let $MYVIMRC="'"$XDG_CONFIG_HOME"'/vim/vimrc" | source $MYVIMRC'
diff --git a/.local/state/python/.gitkeep b/.local/state/python/.gitkeep
new file mode 100644
index 0000000..e69de29
diff --git a/.profile b/.profile
index 5a9b03b..3044c61 100644
--- a/.profile
+++ b/.profile
@@ -60,6 +60,15 @@ fi
 
 # Put local executables on the `$PATH`
 _prepend_to_path "$HOME/.local/bin"
+_prepend_to_path "$PYENV_ROOT/bin"
+
+
+if _command_exists pyenv; then
+    eval "$(pyenv init -)"
+    if pyenv commands 2>/dev/null | grep -qx 'virtualenv-init'; then
+        eval "$(pyenv virtualenv-init -)"
+    fi
+fi
 
 
 # When everything is loaded, show a little welcome message